BUILDING INTEGRATED MOLECULE DETECTION AND MULTIPLEXED CELL IMAGING TOOLS FOR PERSONAL HEALTH

Abstract: Next-generation personal health needs access of data at molecular and cellular levels. This can be achieved by molecule detection and cell imaging, two widely used technologies residing in today’s diagnostic and analytical medical devices. Great success has been made in marketing these devices with reliable performance. However, there remains practical needs for tools that can provide new capabilities, such as integrated detection system and multiplexed, single-cell resolution imaging, which hold promise in offering telemedicine and high-content sample analysis. Building tools like this would open up opportunities in healthcare industry, such as portable genetic disease detection and preclinical drug screening for brain disease treatment. Motivated by these, my research has focused on building integrated molecule detection and multiplexed cell imaging tools, aided by expertise in bioelectronics, nanodevices, and neuroimaging. In this talk, I introduce my work on: 1) integrated DNA chip with all-electrical operation, using graphene and CMOS sensor arrays, respectively; 2) spatially multiplexed cell imaging system, offering multiple signals in one mammalian cell. I will close with a vision of my future research.